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Buspar medication5/16/2023 Taking buspirone with medications that block or stimulate liver enzyme CYP3A4 may change the levels of buspirone in your blood because this enzyme breaks down the drug-your healthcare provider may need to adjust your dosage if you’re taking these medications. fluoxetine see Important Safety Information), SNRIs (serotonin-norepinephrine reuptake inhibitors), trazodone (see Important Safety Information), or any other drug that increases serotonin levels can lead to serotonin syndrome (Wilson, 2022 Simon, 2022). MAOIs are not the only drugs that may cause a serotonin syndrome drug interaction. Serotonin syndrome symptoms include confusion or agitation, muscle twitching or rigidity, increased heart rate, elevated body temperature, nausea/vomiting, high blood pressure, sweating, and dilated pupils ( Simon, 2022).ĭon’t take buspirone within 14 days of taking an MAOI, including (Wilson, 2022): You should not use buspirone with medications known as MAOIs (monoamine oxidase inhibitors), as it can lead to serotonin syndrome, a potentially life-threatening condition. Be sure to inform your healthcare provider about any other medications (prescription, over-the-counter, supplements, etc.) you take. Buspirone drug interactionsīuspirone can cause dangerous drug interactions. Therefore, you should avoid drinking large amounts of grapefruit juice while taking buspirone ( DailyMed, 2021 Wilson, 2022). You should not drink alcohol while taking buspirone (Wilson, 2022). Buspirone should be only taken by pregnant or breastfeeding people when necessary and after consulting with a healthcare provider.Īlcohol can intensify the drowsiness and impairment that buspirone might cause. People with severe liver disease or reduced kidney function should not use buspirone because it’s metabolized by the liver and excreted by the kidneys (Wilson, 2022).īuspirone is a pregnancy Category B drug, meaning there is not enough data to know whether buspirone is safe to take during pregnancy or if the medication is expressed in breast milk. You should not take buspirone if you are allergic to it, especially if you have a severe allergic reaction like hives, swelling, or trouble breathing. Never take two doses at one time ( MedLinePlus, 2019). But you should skip the missed dose if it’s almost time for your next dose. If you miss a dose of buspirone, take it as soon as you remember. Avoid taking this drug with large amounts of grapefruit juice. It doesn’t matter if you take buspirone with or without food, but you should be consistent and take it around the same time each day. The maximum daily dosage is 60 mg (Wilson, 2022). The recommended starting dose for generalized anxiety disorder is 10–15 mg daily, divided into two doses of 7.5 mg or three doses of 5 mg. Generalized anxiety disorder (GAD): symptoms and diagnosisīuspirone hydrochloride tablets are available in 5 mg, 7.5 mg, 10 mg, 15 mg, and 30 mg tablets. SSRIs can reduce libido and make arousal difficult (Wilson, 2022). One off-label use of buspirone includes treating depression when used along with another antidepressant.īuspirone also helps reduce the sexual side effects of SSRI (selective serotonin reuptake inhibitor) medications used to treat depression. However, because buspirone can take two to four weeks to work, it is not used for episodes of acute anxiety (Wilson, 2022).ĭrugs are sometimes used “off-label,” which means that the drug is being used for a condition that it is not FDA-approved to treat. Xanax? Clinical trials have shown that buspirone is as effective as benzodiazepines (like Xanax, Valium, etc.) for generalized anxiety disorder. Short-term relief of the symptoms of anxiety (not for normal stresses of everyday life)Ĭurious about the effects of buspirone vs.This anxiety can interfere with work, school, social interactions, and other aspects of daily life. They may worry about anything and everything, including family, relationships, work, etc. Generalized anxiety disorder (GAD): People with GAD feel excessive anxiety.Buspirone usesīuspirone is approved by the US Food and Drug Administration (FDA) to treat (Wilson, 2022): Today, buspirone is only available as a generic medication-Buspar has been discontinued. The effects begin to kick in after two to four weeks of use (Wilson, 2022). However, buspirone does not work immediately. It has a low risk of dependence or abuse, making it a preferred option for treating anxiety. Unlike benzodiazepines (like diazepam and alprazolam) and barbiturates (like phenobarbital), buspirone is not habit-forming.
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